报告题目：Biomechanics of Red Blood Cells and Related Human Diseases
报告人：Prof. Ming Dao
PI, Director of Nanomechanics Laboratory, Department of Materials Science and Engineering, Massachusetts Institute of Technology， USA
How biological cells’ mechanical / physical properties are related to disease states? Recent progresses in nanomechanics tools in experiments and computer simulations enable unprecedented opportunities to explore this question in depth. Red blood cells (RBCs) are critical for human health as they transport oxygen as well as carbon dioxide in and out of every part of human body. A discocyte RBC has a diameter of about 8 micrometers, while it has to go through the smallest capillaries as small as 3-4 micrometers in diameter, or thin spleen interendothelial slits with a height of 1.2 micrometers or less. Due to the large distortion involved in passing through these tiny openings, a RBC has to maintain appreciable deformability throughout its lifespan. Red blood cell diseases, such as Plasmodium falciparum malaria and sickle cell disease, are known to alter the deformability and adhesion of the diseased RBCs, causing various complications in microcirculation. The talk will first focus on malaria biomechanics, RBC spleen clearance, and related pathology. Recent results on sickle cell biomechanics under transient hypoxia will also be presented for better understanding of the vaso-occlusive crisis, a major complication in sickle cell disease.
Dr. Ming Dao is the Principal Investigator and Director of MIT’s Nanomechanics Laboratory, and a Principal Investigator in the Infectious Diseases Interdisciplinary Research Group of the Singapore-MIT Alliance for Research and Technology (SMART) Center. He obtained his bachelor‘s degree in engineering mechanics from SJTU in 1989, and his PhD in materials science from University of California at San Diego in 1994. He has published more than 120 SCI journal papers (averaging more than 60 citations per paper), and delivered more than 100 invited lectures. He was awarded the Singapore Research Chair Professorship in Bioengineering and Infectious Disease by MIT in 2012, and elected as Fellow by the American Society of Mechanical Engineers (ASME) in 2016 citing his “many seminal contributions in the following areas: i) cell mechanics and human diseases, ii) nanomechanics of advanced materials, and iii) nanoscale materials characterization technology development”.