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Tunicamycins, Quinovosamycins, and Streptovirudins: Potent Activators of the Penicillin Group of Antibiotics

时间:2017年11月09日 17:42 发布人: 浏览次数:[]

[责任编辑]江倩倩 [信息提供]生命学院 

报告题目:Tunicamycins, Quinovosamycins, and Streptovirudins:  Potent Activators of the Penicillin Group of Antibiotics 

报告人:Neil P.J.Price,美国农业部农业利用研究中心 教授  

报告时间:2017年11月10日(周五)上午10:00-12:00  

报告地点:徐汇校区哲生馆一楼会议室  

联系人:贺新义  xyhe@sjtu.edu.cn

报告人简介:

  Dr. Neil Price is a research chemist at the USDA national laboratory in Peoria, Illinois, USA.  He has a PhD from University of London, and has postdoctoral experience in Geneva, Switzerland, in Toulouse, France, and the Complex Carbohydrate Research Center in Athens, University of Georgia.  His talk will focus on the discovery of new tunicamycin-type antibiotics, including the quinovosamycins and streptovirudins.  

  These compounds have potent antibacterial activity, but are also potent inhibitors of protein N-glycosylation so are toxic to mammals. Using a synthetic library, the Price lab has identified lead compounds (TunR1 and TunR2) with reduced toxicity, but that retain the antibacterial activity. Importantly, these compounds are inhibitor of TagO, The first step of teichoic acid biosynthesis in bacteria, and are therefore potent enhancers of the penicillins.  The talk will present data on the discovery of less toxic enhancer of penicillins, based on the lead structure of the tunicamycins,quinovosamycins, and streptovirudins.   

 

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