报告题目：微生物代谢国家重点实验室启智讲坛第二十五讲：NEW Drugs from OLD Pathways - Teaching Nature New Tricks
报告人：Professor Thomas J. Simpson
Alfred Capper Pass Chair of Chemistry
University of Bristol, UK
Elected Fellow of the Royal Society
Elected Fellow of the Royal Society of Edinburgh
Engineering metabolic pathways in microorganisms can provide new antibiotics and other bioactive natural products.The mupirocins, e.g. pseudomonic acid A and thiomarinols isolated from Pseudomonas and Pseudoalteromonas bacteria are antibiotics active against MRSA. Clinical applications are restricted by instability in the former and toxicity in the latter. Using classical biosynthetic methods to understand how they are formed, combined with molecular genetic engineering, novel analogues in which both these limitations can be produced. Similarly, the biosynthetic pathway to the fungal metabolite, tenellin, isolated from Beauvaria bassiana, has been engineered to produce the “extinct” compound, bassianin, and many new compounds for biological evaluation.