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微生物代谢国家重点实验室启智讲坛第二十五讲:NEW Drugs from OLD Pathways - Teaching Nature New Tricks

时间:2017年10月27日 11:07 发布人: 浏览次数:[]

[责任编辑]江倩倩 [信息提供]生命学院 

报告题目:微生物代谢国家重点实验室启智讲坛第二十五讲:NEW Drugs from OLD Pathways - Teaching Nature New Tricks 

报告人:Professor Thomas J. Simpson
      Alfred Capper Pass Chair of Chemistry
      University of Bristol, UK
      Elected Fellow of the Royal Society
      Elected Fellow of the Royal Society of Edinburgh 

报告时间:2017年10月30日(周一)下午13:30-15:00 

报告地点:闵行校区生命学院树华多功能厅(800号) 

联系人:林忆杉 mml@sjtu.edu.cn

报告内容简介:

  Engineering metabolic pathways in microorganisms can provide new antibiotics and other bioactive natural products.The mupirocins, e.g. pseudomonic acid A and thiomarinols isolated from Pseudomonas and Pseudoalteromonas bacteria are antibiotics active against MRSA. Clinical applications are restricted by instability in the former and toxicity in the latter. Using classical biosynthetic methods to understand how they are formed, combined with molecular genetic engineering, novel analogues in which both these limitations can be produced. Similarly, the biosynthetic pathway to the fungal metabolite, tenellin, isolated from Beauvaria bassiana, has been engineered to produce the “extinct” compound, bassianin, and many new compounds for biological evaluation. 

 

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