[责任编辑]李敏妍 [信息提供]药学院
报告主题：DNA Mismatch Repair in Cancer
报告人：Guo-Min Li
Professor, Department of Toxicology, University of Kentucky, College of Medicine
报告时间：2012年12月19日4:00 p.m.
报告地点：药学院五号楼412室
主持人：Professor Tuo Jin
Abstract:
DNA mismatch repair (MMR) is a highly conserved biological pathway in all living organisms, and it plays a critical role in maintaining genomic stability. The genome-maintenance function of the pathway includes correcting DNA biosynthetic errors generated during DNA replication, suppressing DNA recombination between two divergent sequences, and signaling DNA damage response to trigger programmed cell death in cells with severe DNA damage. In this presentation, I will report our recent findings on MMR, which include how the MMR system is precisely regulated by genetic and epigenetic factors, as well as posttranslational modifications, and potential applications of MMR activities in cancer detection and therapy.
