Fabrication of Pharmaceutical Particles Using Electrohydrodynamic Atomization: Examples for Understanding flows and dynamics of particulate systems
[责任编辑]李敏妍 [信息提供]化工学院
报告题目：Fabrication of Pharmaceutical Particles Using Electrohydrodynamic Atomization: Examples for Understanding flows and dynamics of particulate systems
采用电水力雾化方法制造药物颗粒：如何理解颗粒系统的流动和流体力学
报告人：Prof. Chi-Hwa Wang （王启华教授）
Department of Chemical and Biomolecular Engineering，National University of Singapore
报告时间：12月12日（周三）下午15：30
报告地点：建工力学楼（化学化工学院B楼）410会议室
邀请人：肖文德教授（化学化工学院）
Abstract
Particulate science and technology is an interdisciplinary research area with its core being the understanding of the relationships between micro- and macro- scopic properties of particulate materials. In this talk, a few examples are used to illustrate some interesting phenomena associated with the dynamics of particulate systems in pharmaceutical particle fabrication and granular transport processes. This illustration provides an overview of related research projects in the “Particulate Science and Technology Laboratory” at the National University of Singapore.
Through the use of the electrohydrodynamic atomization (EHDA) method, it is possible to generate fine but mono-disperse particles for use in nano-technology and pharmaceutical industries. Controlled delivery devices for therapeutic agents are fabricated using the EHDA technique with tailored release properties. In-vitro and in- vivo characterizations of these EHDA micro- and nano- pharmaceutical particles and fibers are reviewed. A few non-invasive measurements using the Electrical Capacitance Tomography (ECT) and Particle Image Velocimetry (PIV) are evaluated for the on-line monitoring of solids concentration and velocity distributions in pneumatic conveying pipes and vibrated beds. Besides the experimental studies on the flow characterization and profiles of granular materials, theoretical studies are carried out on the investigation of the instabilities of granular material in various flow modes such as shear flow, gravity flow and vibrated granular layers. The driving factors causing the instabilities in the system and the mechanism of these instabilities are also investigated.
At the end of this seminar presentation, a short slide show will be provided to highlight the education and research activities of National University of Singapore at the Faculty of Engineering and Department of Chemical and Biomolecular Engineering and the NRF CREATE Shanghai Jiaotung University (SJTU) Program.
About the Speaker
Dr. Chi-Hwa Wang is currently a Professor of Chemical and Biomolecular Engineering at the National University of Singapore (NUS). He had the following joint appointments in his service to the same university (i) Assistant Dean for Research at the Faculty of Engineering, NUS (2006-2008), and (ii) Faculty Fellow, Singapore-MIT Alliance (2001-2006). He received his B.S. degree (Chemical Engineering) from the National Taiwan University, M.S. degree (Biomedical Engineering) from Johns Hopkins University, M.A. and PhD degrees (both in Chemical Engineering) from Princeton University, respectively.
His current research interests include drug delivery systems and transport & reaction in particulate systems.
He is currently on the editorial boards of Journal of Controlled Release (Elsevier) and Powder Technology (Elsevier). He is an Executive Editor for Advanced Powder Technology ( Elsevier, 2009-2012) and also an Executive Editor for Chemical Engineering Science (Elsevier, effective from Jan. 2013).
