报告人：Xiao-Fan Wang, Ph.D. Professor of Pharmacology and Cancer Biology
Duke University Medical Center
时间：2007年10月26日（周五）下午14：00
地点：生物药学楼8号楼报告厅
报告人简介：Xiao-Fan Wang, Ph.D
Research interests:
The main research interest of his laboratory is to reveal and elucidate the molecular mechanisms of human diseases, such as cancer and immune disorders. The first area of research involves study of TGF-ß signal mechanisms in the context of both cultured cells and animal model systems. They intend to determine the role of Smad proteins, two of which are tumor suppressors mutated in human cancers, in regulating cell proliferation and differentiation. Using Smad3 deficient mouse as a model system, they are currently investigating the involvement of TGF-ß signaling and Smad3 function, as well as crosstalk with the Wnt signaling pathway, in the regulation of mesenchymal stem cell proliferation and differentiation. The second area of research aims to determine the signaling mechanism of cell cycle checkpoint in response to DNA damage and DNA replication block. The main focus is the study of functions of ATM, ATR and Rad17 as key components of the checkpoint pathways in mammalian cells. They intend to determine the mechanism through which the activities of ATM and ATR are activated in response to genotoxic stress and the molecular link between checkpoint and activation of apoptosis. The third area of research aims to determine the mechanisms of tumor progression and metastasis promoted by the activity of a novel protein, termed periostin that is secreted by many types of human tumors, using both cultured cells and animal model systems.
